The mystery of Kodakara-no-yu (Fertility hot spring): A study to verify their efficacy in treating infertility

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  • Kawamura Kazuhiro
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University

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  • 子宝の湯の謎-不妊治療への有効性検証に関する研究
  • コダカラ ノ ユ ノ ナゾ : フニン チリョウ エ ノ ユウコウセイ ケンショウ ニ カンスル ケンキュウ

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Abstract

<p>【Background】</p><p>In Japan, there are hot springs known as “Kodakara-no-yu; fertility hot springs”. However, there has been no study on the efficacy of “Kodakara-no-yu” for infertility. Here, we investigated the possibility of improving ovarian function based on the effect of promoting blood circulation by thermal action, of “Kodakara-no-yu “.</p><p>【Methods】</p><p>The Ca/Na sulfate, bicarbonate, and chloride hot springs (designated as "G" hot springs known as Kodakara-no-yu) and the neutral hypotonic cold mineral hot springs (designated as "P" one without fertility benefits) were used in this study. Female mice were subcutaneously administered an anticancer drug, and four weeks later, follicle development was induced. The next day, the mice were placed in each holding device and locked in a thermostatic chamber kept at 40°C. Two times of bathing were performed for 15 minutes, followed by a 1-hour rest period. Ovulation was induced on the following day and in vitro fertilization was performed.</p><p>【Results】</p><p>The size of anticancer-drug-treated ovaries was significantly smaller than those of controls with a markedly declined follicle number and many cavities in the medulla, indicating the successful development of the ovarian dysfunction model. In this model, the number of ovulated oocytes was significantly higher in the G group compared with P and the non-bathed control (p <0.05). However, the blastocyst formation rate was not different among the three groups.</p><p>【Conclusion】</p><p>In bathing mice with ovarian dysfunction, the " Kodakara-no-yu " increased the number of ovulated oocytes, suggesting that it may have a special effect on restoring follicle development.</p>

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