<p>Lure fishing is a well-known type of fishing that uses artificial lures instead of traditional live baits. Vibratory lure is a kind of lures performs greater vibration behavior than other kinds of lures. In common, more excellent vibration behavior of vibrating lure can attract carnivorous fish more efficiently. Up to now, lure design is generally based on the intuition of the designer, and there is little academic research on vibrating lure. In this study, we build the finite element model of a commercial vibration lure using a 3D scanner at first. Then, fluid–structure interaction (FSI) analysis is carried out to reproduce underwater motion of the vibration lure, where we can calculate the frequency of the flow induced vibration (FIV). Finally, in order to obtain the best FIV behavior of the vibration lure, based on the simulation results of FSI analysis, we perform structural design optimization of the vibration lure using the Box-Behnken design method, which belongs to the response surface methodology. In the structural design optimization, we set three design variables, which are the positions (x and z) of the weight placed in the lower part of the lure, and the eye position (i.e., the knot position between fishing line and lure) along the lure body. According to optimal results, the highest frequency of the FIV can reach 7.07 Hz. However, the present work is still in the early stage of the academic research on lure design, we aim to develop more optimization method for lure design that make lure fishing more interesting for both beginners and anglers.</p>