Free Carnitine Levels During Cardiac Peri-Operative Periods with Cardiopulmonary Bypass in Pediatric Patients with Congenital Heart Diseases : Secondary Publication
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- Tanabe Yuka
- Department of Pediatrics, Shimane University Faculty of Medicine
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- Yamada Kenji
- Department of Pediatrics, Shimane University Faculty of Medicine
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- Nakashima Shigeki
- Department of Pediatrics, Shimane University Faculty of Medicine
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- Yasuda Kenji
- Department of Pediatrics, Shimane University Faculty of Medicine
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- Tachi Maiko
- Department of Cardiovascular Surgery, Shimane University Faculty of Medicine
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- Fujimoto Yoshifumi
- Department of Cardiovascular Surgery, Shimane University Faculty of Medicine
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- Kobayashi Hironori
- Department of Pediatrics, Shimane University Faculty of Medicine
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- Taketani Takeshi
- Department of Pediatrics, Shimane University Faculty of Medicine
書誌事項
- タイトル別名
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- Free Carnitine Levels During Cardiac Peri-Operative Periods with Cardiopulmonary Bypass in Pediatric Patients with Congenital Heart Diseases—Secondary Publication
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抄録
<p>Objective: Carnitine is essential for long-chain fatty acid metabolism in order to produce biological energy via the mitochondria. Carnitine deficiency can result in cardiomyopathy, hypoglycemia, and other complications. This study aimed to determine how plasma carnitine levels changed before and after open-heart surgery with cardiopulmonary bypass (CPB) in children with congenital heart disease.</p><p>Methods: We measured free carnitine (C0) levels in the blood before and after CPB, as well as on each day 7 days after the procedure.</p><p>Results: We treated 50 patients with average age of 35±49 months. We identified 19 patients with extracardiac complications, including eight with chromosomal disorder, three with suspected chromosomal disorder, four preterm births, two with digestive disorders, and two with other complications. C0 levels immediately before CPB were 55.8±24.4 nmol/mL, whereas immediately after CPB were significantly lower [33.5±12.9 nmol/mL (the ratio of C0 level before and after CPB were: 64±19%, p<0.01)]. Although there was no significant difference in aortic clamp time, CPB time, or pre-operative blood data, the presence of extracardiac complications was significantly correlated to the C0 level just after CPB (odds ratio, OR: 3.385, 95% confidence interval, CI: 1.858–3.385, p<0.01).</p><p>Conclusions: C0 dropped temporarily after CPB and then returned three days later. Since the decrease in C0 after CPB was linked to extracardiac complications in children with congenital heart disease, monitoring pre- and post-operative C0 concentration may be warranted in these patients.</p>
収録刊行物
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- Journal of Pediatric Cardiology and Cardiac Surgery
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Journal of Pediatric Cardiology and Cardiac Surgery 7 (1), 18-26, 2023-03-31
特定非営利活動法人 日本小児循環器学会