Effect of birth season on allergic rhinitis and cedar pollinosis considering allergen and vitamin D exposure: The Japan Environment and Children's study (JECS)
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- Kojima Reiji
- Department of Health Sciences, School of Medicine, University of Yamanashi
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- Shinohara Ryoji
- Center for Birth Cohort Studies, University of Yamanashi
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- Kushima Megumi
- Center for Birth Cohort Studies, University of Yamanashi
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- Horiuchi Sayaka
- Center for Birth Cohort Studies, University of Yamanashi
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- Otawa Sanae
- Center for Birth Cohort Studies, University of Yamanashi
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- Miyake Kunio
- Department of Health Sciences, School of Medicine, University of Yamanashi
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- Yokomichi Hiroshi
- Department of Health Sciences, School of Medicine, University of Yamanashi
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- Akiyama Yuka
- Department of Health Sciences, School of Medicine, University of Yamanashi
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- Ooka Tadao
- Department of Health Sciences, School of Medicine, University of Yamanashi
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- Yamagata Zentaro
- Department of Health Sciences, School of Medicine, University of Yamanashi Center for Birth Cohort Studies, University of Yamanashi
Abstract
<p>Background: The relationship between the season of birth, allergen sensitization, and allergic rhinitis have been inconsistent, and there are no studies that simultaneously consider vitamin D and allergen exposure. This study aimed to determine the associations between the season of birth, house dust mite (HDM) and Japanese cedar pollen (JCP) sensitization, and allergic rhinitis and pollinosis, while taking vitamin D levels and allergen exposure into account.</p><p>Methods: This study included 4323 participants in the Sub-Cohort Study of the Japan Environment and Children's Study. A logistic regression model was used to analyze the association between the season of birth and sensitization to JCP or HDM (judged by specific immunoglobulin E) at age 2 and allergic rhinitis or pollinosis at age 3, adjusted for HDM or JCP exposure and vitamin D levels with potential confounders.</p><p>Results: Participants born in spring or summer were more likely to have pollinosis than were those born in winter (adjusted odds ratio [aOR]: 2.08, 95% confidence interval [CI]: 1.13-3.82 for spring; aOR: 1.89, 95% CI: 1.03-3.47 for summer). Participants born in summer were more likely to have HDM sensitization than were those born in winter (Der p 1, aOR: 1.53, 95% CI: 1.10-2.15; Der f 1, aOR: 1.44, 95% CI: 1.03-2.01). Exposure to JCP and HDM were associated with pollinosis and HDM sensitization, respectively.</p><p>Conclusions: Spring and summer births were associated with the development of pollinosis, and summer birth was associated with HDM sensitization, even when vitamin D and allergen exposure were considered. Further studies on mechanisms other than vitamin D and allergen exposure are required.</p>
Journal
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- Allergology International
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Allergology International 72 (3), 411-417, 2023
Japanese Society of Allergology
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Details 詳細情報について
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- CRID
- 1390015210901494272
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- ISSN
- 14401592
- 13238930
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- KAKEN
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- Abstract License Flag
- Disallowed