Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology - secondary publication

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  • Sato Sakura
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
  • Yanagida Noriyuki
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
  • Ito Komei
    Department of Allergy, Aichi Children's Health and Medical Center
  • Okamoto Yoshitaka
    Department of Otorhinolaryngology, Chiba Rosai Hospital
  • Saito Hirohisa
    Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development
  • Taniguchi Masami
    Department of Allergy, Shonan Kamakura General Hospital
  • Nagata Makoto
    Department of Respiratory Medicine, Saitama Medical University Allergy Center, Saitama Medical University Hospital
  • Hirata Hirokuni
    Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center
  • Yamaguchi Masao
    Department of Internal Medicine, Teikyo University Chiba Medical Center
  • Pawankar Ruby
    Department of Pediatrics, Nippon Medical School
  • Ebisawa Motohiro
    Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital

抄録

<p>Background: Anaphylaxis is a potentially fatal severe systemic hypersensitivity reaction that causes symptoms in multiple organs such as the skin, respiratory tract, and gastrointestinal tract; however, no nationwide epidemiological survey on anaphylaxis has been conducted in Japan. This survey aimed to elucidate the triggers and treatment of anaphylaxis in Japan.</p><p>Methods: Between February 2015 and October 2017, we prospectively collected clinical data on the triggers and treatment of patients who developed anaphylaxis or were admitted to the emergency room with anaphylaxis in the training and teaching facilities of the Japanese Society of Allergology.</p><p>Results: This study included 79 of the 451 affiliated facilities (18%), and a total of 767 patients were enrolled; 73% of them were aged <18 years and 7% had in-hospital triggers. The most common triggers were food (68%), drugs (12%), food-dependent exercise-induced anaphylaxis (5%), insects (4%), and oral immunotherapy (3%), with drugs being the most common in-hospital trigger and food being the most common out-of-hospital trigger. Intramuscular injection of adrenaline was administered therapeutically to 38% of the patients, with 10% requiring multiple doses. Adrenaline auto-injectors were used in 12% of out-of-hospital patients.</p><p>Conclusions: The present survey revealed the most common triggers and treatments for anaphylaxis in Japan. Self-management and adrenaline administration as first-line treatment may not be done sufficiently. Therefore, it is necessary to thoroughly educate and train patients and physicians about anaphylaxis.</p>

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