THE INFLUENCE OF SENSITIZATION TO <i>ASPERGILLUS </i>AND <i>ALTERNARIA </i>IN ADULT BRONCHIAL ASTHMATICS MANAGED VIA YOKOHAMA CITY SEIBU HOSPITAL'S COORDINATED-CARE SYSTEM

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  • Tsuburai Takahiro
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Ueno Junko
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Komase Yuko
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Oyama Baku
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Muraoka Hiromi
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Shinozaki Yusuke
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Nishiyama Kazuhiro
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Tanaka Satoshi
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Nishi Yoshihiro
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Numata Yu
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Hida Naoya
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Inoue Takeo
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine

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Other Title
  • 気管支喘息病診連携症例におけるアスペルギルスおよびアルテルナリア感作と影響
  • キカンシ ゼンソクビョウシン レンケイ ショウレイ ニ オケル アスペルギルス オヨビ アルテルナリア カンサ ト エイキョウ

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Abstract

<p>Background: The sensitizations to various fungal allergens influence to exacerbation of bronchial asthma. Aspergillus (Asp) and Alternaria (Alt) were one of important fungal allergens for asthma.</p><p>Aim and Methods: To investigate the influence of sensitization to Asp or Alt in adult asthmatics managed via our asthma coordinated-care system, we recruited 119 patients (91 women) who were measured IgE for Asp (IgE-Asp) and IgE for Alt (IgE-Alt) at three times during two years,</p><p>Results: In 119 patients, we detected positive IgE for Asp (IgE-Asp(+)) in 19 patients and positive IgE for Alt (IgE-Alt(+)) in 11 patients. 9 patients showed positive both of them. During two years, 7 patients became positive IgE-Asp and 3 cases became negative. And also, 3 cases became positive IgE-Alt and 3 cases became negative. At baseline, serum IgE, IgG4, and inhaled corticosteroid (ICS) dose of the group with IgE-Asp (+) or IgE-Alt (+), were significant higher than those of negative group. Among three groups, there was no significant change about other parameters at baseline, exacerbation frequency, or the change of parameters during two years.</p><p>Conclusion: The sensitizations to Asp or Alt were present in 19 asthmatics (16%) managed via our coordinate-care system. During 2 years, there was not significant change at exacerbation frequency among three groups, but the levels of IgE, IgG4, or ICS dose were significantly higher at IgE-Asp (+) or IgE-Alt (+) group than negative group. In the asthma management, it was considered necessary to pay attention to the sensitization to Asp or Alt.</p>

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