Diagnostic Criteria for Slowly Progressive Type 1 Diabetes Mellitus (Slowly Progressive Insulin-Dependent Diabetes Mellitus) - A Report by the Committee on Type 1 Diabetes, Japan Diabetes Society -

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  • Shimada Akira
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University
  • Kawasaki Eiji
    Diabetes Center, Shin-Koga Hospital
  • Abiru Norio
    Midori Clinic
  • Awata Takuya
    Pancreatic Islet Cell Transplantation Center, National Center for Global Health and Medicine
  • Oikawa Yoichi
    Department of Endocrinology and Diabetes, School of Medicine, Saitama Medical University
  • Osawa Haruhiko
    Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine
  • Kajio Hiroshi
    Department of Diabetes, Endocrinology and Metabolism, Center Hospital of the National Center for Global Health and Medicine
  • Kozawa Junji
    Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University
  • Takahashi Kazuma
    Department of Basic Nursing Science, School of Nursing, Iwate Prefectural University
  • Chujo Daisuke
    Center for Clinical Research, Toyama University Hospital
  • Noso Shinsuke
    Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine
  • Fukui Tomoyasu
    Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Showa University School of Medicine
  • Miura Junnosuke
    Division of Diabetology and Metabolism, Department of Internal Medicine Tokyo Women's Medical University School of Medicine
  • Yasuda Kazuki
    Department of Diabetes, Endocrinology and Metabolism, Kyorin University School of Medicine
  • Yasuda Yasufumi
    Division of Health Sciences, Department of Public Health, Kobe University Graduate School of Health Sciences
  • Imagawa Akihisa
    Department of Internal Medicine (I), Faculty of Medicine, Osaka Medical and Pharmaceutical University
  • Ikegami Hiroshi
    Department of Endocrinology, Metabolism and Diabetes, Kindai University Faculty of Medicine <sup>*</sup>Chairman

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Other Title
  • 緩徐進行1型糖尿病の診断基準（2023）―1型糖尿病における新病態の探索的検討委員会報告―

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Abstract

<p>The diagnostic criteria for slowly progressive type 1 diabetes mellitus (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by the "Committee on Type 1 Diabetes" of the Japan Diabetes Society. The following three criteria are all required for a definitive diagnosis of SPIDDM: 1) the presence of islet-associated autoantibody at some time point during the disease course; 2) the absence of ketosis or ketoacidosis at the diagnosis of diabetes and no need for insulin treatment to correct hyperglycemia immediately after the diagnosis principally; and 3) a gradual decrease in insulin secretion over time, with insulin treatment required more than 3 months after the diagnosis of diabetes, and the exhaustion of endogenous insulin secretion (fasting serum C-peptide < 0.6 ng/mL) at the last observed time point. Should a patient meet only criteria 1 and 2 but not 3, they should be diagnosed with "slowly progressive type 1 diabetes mellitus (probable)" because of their non-insulin-dependent diabetic state.</p>

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