Study on the development of vitamin D analogs and structural analysis of the vitamin D receptor
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- Yamamoto Keiko
- Faculty of Pharmaceutical Sciences, Showa Pharmaceutical University
Bibliographic Information
- Other Title
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- ビタミン D アナログの創製と受容体の構造解析に関する研究
- ビタミン Dアナログ ノ ソウセイ ト ジュヨウタイ ノ コウゾウ カイセキ ニ カンスル ケンキュウ
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Abstract
Active vitamin D, 1 α,25-dihydroxyvitamin D 3 [1,25-(OH) 2 D 3 ] is a hormone that plays an essential role in calcium homeostasis and bone metabolism. 1,25-(OH) 2 D 3 is also involved in cell differentiation and proliferation, and immunomodulation. 1,25-(OH) 2 D 3 and its analogs exhibit these effects by binding to the vitamin D receptor which is a ligand-dependent transcription factor. The vitamin D receptor belongs to the nuclear receptor superfamily which includes receptors for steroids, retinoids and thyroid hormones. We developed various vitamin D analogs which specifically bind to the vitamin D receptor, and then we classified these analogs into agonist, a partial agonist and antagonist for the receptor by judging from their biological activities. Using crystal structural analysis and solution structural analysis we clarified the three-dimensional structure of the vitamin D receptor and interactions between vitamin D analogs and the vitamin D receptor. The results indicated that agonism, partial agonism and antagonism of the vitamin D receptor by the ligand binding were structure-biologically clarified.
Journal
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- VITAMINS
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VITAMINS 96 (7), 281-290, 2022-07-25
THE VITAMIN SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390015487571971200
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- NII Book ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL BIB ID
- 032300116
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
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- Abstract License Flag
- Disallowed