Effect of O<sub>2</sub> concentration on arteriole diameter near stimulated neurons in the cortex

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  • Sato Tatsuya
    Division of Mechanical Engineering, Graduate School of Engineering and Science, Shibaura Institute of Technology
  • Sasaki Saori
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University
  • Sera Toshihiro
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University
  • Kudo Susumu
    Department of Mechanical Engineering, Faculty of Engineering, Kyushu University

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<p>The brain requires O2 and nutrition to keep functioning. It is known that O2 concentration converts the polarity of vessel response near the activated neuron in the hippocampus. However, it remains unclear whether O2 concentration converts the polarity in the cortex. We investigated the comparison of the arteriole response near the stimulated neurons in cerebral cortex slices between 95% and 20% O2 concentration in medium. We showed that the diameter of the blood vessels decreased under 95% O2 concentration when the pyramidal cells near the blood vessels were stimulated and increased under 20% O2 concentration with the same stimulation.</p>

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