閉塞性睡眠時無呼吸症候群の上気道シミュレーション

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  • Upper airway simulation of obstructive sleep apnea syndrome

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<p>Because of the difficulty in measuring airflow dynamics, computational fluid dynamic (CFD) simulations were being performed to investigate in detail the upper airway airflow in obstructive sleep apnea syndrome (OSAS). However, the relationship between the severity of OSAS as measured by the apnea hypopnea index (AHI) and airflow dynamics is unclear. In this study, to investigate the correlations between AHI and pressure drops in the nasal cavity and throat and the minimum cross-sectional area of the throat, CFD simulations mimicking human snoring during sleep were performed. The 3D models were reconstructed based on computed tomographic images of OSAS including four mild and six severe cases in the open-mouth state that is a common form of snoring. Each relationship was evaluated using Spearman’s correlation coefficient. The correlation between AHI and pressure drop in the nasal cavity was 0.745, indicating a significant correlation. There was a tendency for weak correlations between AHI and throat pressure drop and the minimum cross-sectional area of the throat. These results suggest that nasal cavity pressure drop affects the severity of OSAS.</p>

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