Effects of Treadmill Exercise and Swimming on Spontaneous Developed Knee Osteoarthritis in Senescence-accelerated Mouse Prone 8

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  • Norimatsu Kosuke
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Nakanishi Kazuki
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Kakimoto Shogo
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Nojima Nao
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Tani Akira
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Matsuzaki Ryoma
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Matsuoka Teruki
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Inadome Masaki
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Kato Yuki
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Tachibe Yuta
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University
  • Takada Seiya
    Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Science
  • Otsuka Shotaro
    Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Science
  • Sumizono Megumi
    Department of Rehabilitation, Kyushu University of Nursing and Social Welfare
  • Sakakima Harutoshi
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University

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  • トレッドミル運動と水泳が老化促進マウスの自然発症型変形性膝関節症に及ぼす影響

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Abstract

<p>This study investigated the effects of treadmill exercise and swimming on spontaneous developed knee osteoarthritis in the senescence-accelerated mouse prone 8 (SAMP8). Twenty-two weeks old SAMP8 mice were randomly divided into the No-exercise group, treadmill exercise group, and swimming group (n = 6 in each group). Treadmill exercise was performed at the speed of 10-12 m/min, and swimming was performed at a water temperature of 37-38℃ for 15 min/day, 5 day a week for 6 weeks. After exercise intervention, we examined the knee joint angle, width of the knee joint, stride length, and knee joint histological changes. Comparison with No-exercise group, both exercise groups were improved the knee joint angle and stride length. In addition, increased type II collagen positive chondrocyte, reduced matrix metalloproteinase (MMP)-13 positive chondrocyte, and tumor necrosis factor (TNF)-α positive cells in the synovium were observed in both exercise groups. Notably, the swimming group significantly improved the stride length and increased the ratio of type II collagen positive chondrocyte that is important protein maintaining a chondrocyte homeostasis. This study suggested that both exercise regimens alleviate age-related OA alteration, which improved the knee joint angle and stride length. The swimming may be beneficial in maintaining homeostasis for age-related OA joint and improving age-related gait disturbance.</p>

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