A possible enhancement of anti-cancer effect of tocotrienol in malignant mesothelioma by 6-<i>O</i>-carboxypropyl-alpha-tocotrienol, an ether derivative of tocotrienol

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  • Ishii Kyota
    Laboratory of Molecular Bromacology, Graduate School of Food and Nutritional Sciences, Toyo University
  • Yano Tomohiro
    Laboratory of Molecular Bromacology, Graduate School of Food and Nutritional Sciences, Toyo University Research institute of Life Innovation, Toyo University

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Other Title
  • トコトリエノールエーテル誘導体化による抗がん作用増強の可能性 ―悪性中皮腫を用いた解析―（特集「ビタミン誘導体による人工触媒系の開発および医療応用研究の最前線」（第 73 回大会シンポジウム））
  • トコトリエノールエーテル誘導体化による抗がん作用増強の可能性 : 悪性中皮腫を用いた解析
  • トコトリエノールエーテル ユウドウタイカ ニ ヨル コウガン サヨウ ゾウキョウ ノ カノウセイ : アクセイ チュウヒシュ オ モチイタ カイセキ

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Abstract

6-O-Carboxypropyl-alpha-tocotrienol (α-T3E) is an anti-cancer agent that exhibits cytotoxicity against cancer cells, including malignant mesothelioma (MM) cells. However, the mechanism underlying this cytotoxicity remains unclear and we have studied to explain this mechanism. In the study, we demonstrated that α-T3E broke proteasome homeostasis thought simultaneous inhibition of signal transducer and activator of transcription 3 (STAT3) and nuclear respiratory factor 1 (NRF1) in MM cells and that α-T3E induced endoplasmic reticulum (ER) stress, which induces cell death to cancer cells, in MM cells. These results indicate that α-T3E exhibits cytotoxicity against cancer cells by inhibiting proteasome function and inducing ER stress. In this review, we summarize the proteasome inhibitory effect of α-T3E and explain the effectiveness of α-T3E in MM therapy.

Journal

  • VITAMINS

    VITAMINS 96 (10), 435-437, 2022-10-25

    THE VITAMIN SOCIETY OF JAPAN

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