THE RELATIONSHIP AMONG BRONCHIAL HYPERSENSITIVITY, BRONCHIAL HYPER REACTIVITY, AND BRONCHIAL HYPERRESPONSIVENESS IN ASTOGRAPH

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  • Tsuburai Takahiro
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Usuba Ayano Tsukune
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Komase Yuko
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Oyama Baku
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Muraoka Hiromi
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Shinozaki Yusuke
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Nishiyama Kazuhiro
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Ueno Junko
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Nishi Yoshihiro
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Numata Yu
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Tanaka Satoshi
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine
  • Yamaguchi Hiromichi
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Yamaguchi Respiratory and Dermatology Clinic
  • Hida Naoya
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
  • Inoue Takeo
    Department of Respiratory Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital Department of Respiratory Medicine, St. Marianna University School of Medicine

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Other Title
  • アストグラフ法を用いた気道過敏性検査の判定における気道感受性，気道反応性，発作閾値の関連
  • アストグラフホウ オ モチイタ キドウ カビンセイ ケンサ ノ ハンテイ ニ オケル キドウ カンジュセイ,キドウ ハンノウセイ,ホッサ イキチ ノ カンレン

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<p>Background: Bronchial hyperresponsiveness testing is useful for diagnosing and predicting the risk of bronchial asthma attacks. The Astograph is a tidal breathing method often used in as bronchial provocation testing in Japan. The minimum methachorine dose (Dmin) indicates bronchial sensitivity and is used mainly as an index of bronchial hyperresponsiveness. However, Dmin does not measured hyperresponsiveness, it cannot be compared directly with PC20 in standard methods using FEV1.</p><p>Methods: We investigated the relationship among sensitivity, reactivity, and hyperresponsiveness with the Astograph. We recruited 142 patients with confirmed or suspected bronchial asthma from outpatient clinic at St. Marianna University School of Medicine, Yokohama City Seibu Hospital. We calculated Dmin, SGrs/Grscont, PD35Grs, and PD15Grs compared them as bronchial hyperresponsiveness indices.</p><p>Results: Subjects had suspected asthma (n=103), or required assessment of asthma remission (n=39). There were significant relationships between logDmin and logPD35Grs (r=0.838, p<0.001), and between parameters and SGrs/Grscont (log PD35Grs r=-0.504, p<0.001, strong, logDmin: r=-0.191, p=0.023, weaker). Among subjects positive for hypersensitivity, (Dmin<10), 38 (36.5%) showed negative hyperresponsiveness (PD35Grs>25). PD15Grs was a strongly and significantly correlated with Dmin and PD35Grs. The ROC curve to detect PD35Grs<25, showed that the cutoff of PD15Grs was 10.7 (AUC 0.983, sensitivity 0.984, specificity 0.905).</p><p>Conclusion: In Astograph, evaluation of bronchial hyperresponsiveness, we focused on relationship differences between sensitivity and reactivity, and hyperresponsiveness. We revealed the usefulness of the PD15Grs evaluation method.</p>

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