Prognostic Importance of B-Type Natriuretic Peptide Level in Patients Undergoing Catheter Ablation for Atrial Fibrillation
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- Kawaji Tetsuma
- Department of Cardiology, Mitsubishi Kyoto Hospital Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Shizuta Satoshi
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Aizawa Takanori
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Nishiwaki Shushi
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Yoshizawa Takashi
- Department of Cardiology, National Hospital Organization Kyoto Medical Center
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- Nishiuchi Suguru
- Department of Cardiovascular Medicine, Tenri Hospital
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- Kato Masashi
- Department of Cardiology, Mitsubishi Kyoto Hospital
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- Yokomatsu Takafumi
- Department of Cardiology, Mitsubishi Kyoto Hospital
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- Miki Shinji
- Department of Cardiology, Mitsubishi Kyoto Hospital
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Abstract
<p>Background: This study assessed the prognostic importance of B-type natriuretic peptide (BNP) concentrations for clinical events after catheter ablation for atrial fibrillation (AF).</p><p>Methods and Results: We enrolled 1,750 consecutive patients undergoing initial AF ablation whose baseline BNP data were available from a large-scale multicenter observational cohort (TRANQUILIZE-AF Registry). The prognostic impact of BNP concentration on clinical outcomes, including recurrent tachyarrhythmias and a composite of heart failure (HF) hospitalization or cardiac death, was evaluated. Median baseline BNP was 94.2 pg/mL. During a median follow-up of 2.4 years, low BNP (<38.3 pg/mL) was associated with lower rates of recurrent atrial tachyarrhythmias than BNP concentrations ≥38.3 pg/mL (19.9% vs. 30.6% at 3 years; P<0.001) and HF (0.8% vs. 5.3% at 3 years; P<0.001). Multivariable Cox regression analyses revealed that low BNP was independently associated with lower risks of arrhythmia recurrence (hazard ratio [HR] 0.63; 95% confidence interval [CI] 0.47–0.82; P<0.001) and HF (HR 0.17; 95% CI 0.04–0.71; P=0.002). The favorable impact of low BNP on arrhythmia recurrence was prominent in patients with paroxysmal, but not non-paroxysmal, AF, particularly among those with long-standing AF.</p><p>Conclusions: Low BNP concentrations had a favorable impact on clinical outcomes after AF ablation. The heterogeneous impact of baseline BNP concentrations on arrhythmia recurrence for the subgroups of patients divided by AF type warrants future larger studies with longer follow-up periods.</p>
Journal
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- Circulation Journal
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Circulation Journal 87 (12), 1730-1739, 2023-11-24
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390016759113509120
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 033193514
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- PubMed
- 37743520
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
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- Abstract License Flag
- Disallowed