SARS-CoV-2 S1-RBD IgG titers before and after third heterologous booster vaccination with Moderna COVID-19 vaccine in hemodialysis patients
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- Okuda Kosuke
- Okuda Clinic
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- Takahashi Azusa
- Okuda Clinic
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- Furusawa Yoichi
- Okuda Clinic
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- Takahashi Hideaki
- Okuda Clinic
Bibliographic Information
- Other Title
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- 血液透析患者におけるモデルナ社製COVID-19ワクチン3回目異種ブースター接種前後のSARS-CoV-2 S1-RBD IgG抗体価の検討
- ケツエキ トウセキ カンジャ ニ オケル モデルナシャセイ COVID-19 ワクチン 3カイメ イシュ ブースター セッシュ ゼンゴ ノ SARS-CoV-2 S1-RBD IgG コウタイカ ノ ケントウ
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Abstract
<p>We measured Abbottʼs S1-RBD IgG antibody titers before and after the third dose of Modernaʼs COVID-19 vaccine in hemodialysis (HD) patients, and examined factors affecting antibody titers. We used Pfizerʼs BNT162b2 (Pfizer) until the second vaccination, and Modernaʼs mRNA-1273 (Moderna) for the third vaccination 6 months after the second vaccination. Antibody titers increased markedly from a median of 275 (149-571) AU/mL before vaccination to 29,737 (14,984-46,185) AU/mL (108.1-fold) one month after vaccination. Multiple regression analysis showed that post-immunization antibody titers were lower in steroid-naive patients, and were also lower in patients with a lower BMI with the exception of those with a BMI of 30 or higher. The results suggest that hemodialysis patients who show emaciation or take steroids need to take more care regarding infection protection after vaccination.</p>
Journal
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- Nihon Toseki Igakkai Zasshi
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Nihon Toseki Igakkai Zasshi 56 (11), 429-435, 2023
The Japanese Society for Dialysis Therapy
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Details 詳細情報について
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- CRID
- 1390016880929652864
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- NII Book ID
- AN10432053
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- ISSN
- 1883082X
- 13403451
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- NDL BIB ID
- 033213525
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
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- Abstract License Flag
- Disallowed