Acute hepatitis B flare after delivery and discontinuation of nucleotide analog treatment to prevent mother-to-child transmission: a case report

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  • Hatayama Yasuki
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Sugiyama Harutoshi
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Murakami Daisuke
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Oura Hirotaka
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Shima Yukiko
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Shirato Miho
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Nishino Takayoshi
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Arai Makoto
    Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center
  • Kato Naoya
    Department of Gastroenterology, Graduate School of Medicine, Chiba University

Bibliographic Information

Other Title
  • 母子感染予防目的で核酸アナログ製剤が投与され，出産後の中止後にB型肝炎の急性増悪を来した一例
  • ボシ カンセン ヨボウ モクテキ デ カクサン アナログ セイザイ ガ トウヨ サレ,シュッサン ゴ ノ チュウシ ゴ ニ Bガタ カンエン ノ キュウセイ ゾウアク オ キタシタ イチレイ

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Abstract

<p>A Japanese woman in her 30s was diagnosed with hepatitis B surface antigen positivity during pregnancy with her first child. Her liver function was normal; however, high viral load was observed. In accordance with the guidelines, a nucleic acid analog was administered starting at 28 weeks' gestation. The baby was delivered nearly at term, and the nucleic acid analog was discontinued one day prior to the delivery. Liver dysfunction was observed two months after the analog was discontinued, and the patient was restarted on nucleic acid analog treatment. There are many issues to be resolved, including whether nucleic acid analogs should be discontinued immediately following delivery or continued for certain time or whether breastfeeding should continue during nucleic acid analog treatment.</p>

Journal

  • Kanzo

    Kanzo 64 (12), 653-655, 2023-12-01

    The Japan Society of Hepatology

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