A case of prolonged loss of consciousness due to overdose of Tizanidine hydrochloride

DOI
  • Kobana Satoshi
    Kyorin University Hospital Trauma and Critical Care Center
  • Yoshikawa Kei
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Ogino Satoyuki
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Mochida Yuki
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Kaita Yasuhiko
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
  • Yamaguchi Yoshihiro
    Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine

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Other Title
  • チザニジン塩酸塩の過量内服により意識障害が遷延した１例

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<p>We report a case of prolonged loss of consciousness due to tizanidine hydrochloride overdose. A man in his 50s with depression and back pain was brought to the hospital after tizanidine hydrochloride overdose (52 mg). His presenting consciousness level was GCS : E1V1M1, with bradycardia and pupillary constriction. After 10 hours, his consciousness level improved. Although the drug’s half-life is 1.5 h, the prolonged unconsciousness was caused by the large dose and the drug’s slow metabolism. Moreover, the parasympathetic nervous system became dominant, resulting in cholinergic toxidrome-like symptoms. In conclusion, tizanidine hydrochloride overdose should be considered in patients exhibiting these features.</p>

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