A case of prolonged loss of consciousness due to overdose of Tizanidine hydrochloride
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- Kobana Satoshi
- Kyorin University Hospital Trauma and Critical Care Center
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- Yoshikawa Kei
- Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
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- Ogino Satoyuki
- Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
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- Mochida Yuki
- Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
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- Kaita Yasuhiko
- Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
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- Yamaguchi Yoshihiro
- Department of Trauma and Critical Care Medicine, Kyorin University School of Medicine
Bibliographic Information
- Other Title
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- チザニジン塩酸塩の過量内服により意識障害が遷延した1例
Abstract
<p>We report a case of prolonged loss of consciousness due to tizanidine hydrochloride overdose. A man in his 50s with depression and back pain was brought to the hospital after tizanidine hydrochloride overdose (52 mg). His presenting consciousness level was GCS : E1V1M1, with bradycardia and pupillary constriction. After 10 hours, his consciousness level improved. Although the drug’s half-life is 1.5 h, the prolonged unconsciousness was caused by the large dose and the drug’s slow metabolism. Moreover, the parasympathetic nervous system became dominant, resulting in cholinergic toxidrome-like symptoms. In conclusion, tizanidine hydrochloride overdose should be considered in patients exhibiting these features.</p>
Journal
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- KANTO Journal of Japanese Association for Acute Medicine
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KANTO Journal of Japanese Association for Acute Medicine 44 (4), 385-388, 2023-12-28
Japanese Association for Acute Medicine of Kanto
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Details 詳細情報について
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- CRID
- 1390017135055426560
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- ISSN
- 24342580
- 0287301X
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- Text Lang
- ja
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- Data Source
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- JaLC
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- Abstract License Flag
- Disallowed