A Case of a Patient with Hemophilia a Who Underwent Hepatic Resection with Management by Continuous Administration of Factor VIII

DOI Web Site 8 References
  • Shindate Masataka
    Division of Digestive Surgery, Department of Surgery, Nihon University School of Medicine
  • Yamazaki Shintaro
    Division of Digestive Surgery, Department of Surgery, Nihon University School of Medicine
  • Aramaki Osamu
    Division of Digestive Surgery, Department of Surgery, Nihon University School of Medicine
  • Yoshida Nao
    Division of Digestive Surgery, Department of Surgery, Nihon University School of Medicine
  • Yoshida Naoki
    Division of Digestive Surgery, Department of Surgery, Nihon University School of Medicine
  • Masuda Shinobu
    Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine
  • Okamura Yukiyasu
    Division of Digestive Surgery, Department of Surgery, Nihon University School of Medicine

Bibliographic Information

Other Title
  • 第Ⅷ因子製剤の持続投与による管理で肝切除を施行した血友病 A 患者の 1 例

Abstract

<p>Hemophilia A is a disease characterized by bleeding tendency due to abnormal coagulation factor VIII. Thereare few reports on perioperative management during hepatic resection. In this report, we describe a case in whichliver resection was safely performed in a hemophilia A patient by continuous perioperative administration of factor VIII. The patient, an 82-year-old man, was found to have a 32 mm hepatocellular carcinoma in the S8 of theliver during follow-up of chronic hepatitis C. The liver damage was A, APTT was prolonged to 62.3 seconds, andfactor VIII activity was decreased to 7%. Preoperative administration of Factor VIII confirmed improvement incoagulability, and partial hepatectomy was performed. Postoperatively, the needed factor VIII dose was estimatedby APTT and administered continuously. There were no postoperative complications. If immediate measurementof factor VIII activity was difficult, perioperative management was possible by continuous administration of factorVIII under APTT monitoring.</p>

Journal

References(8)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top