A case of localized colorectal amyloidosis in a patient with multiple myeloma

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  • Hiraide Akiri
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Ojiro Keisuke
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Arahata Kyoko
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Katayama Tadashi
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Takarabe Sakiko
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Nakamura Kenji
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Kishikawa Hiroshi
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital
  • Nishida Jiro
    Department of Gastroenterology, Tokyo Dental College Ichikawa General Hospital

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  • 多発性骨髄腫の診断契機となった限局性大腸アミロイドーシスの1例

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Abstract

<p>A man in his 60s had a 6-month history of back pain and abdominal distension. He was referred to our hospital with suspected colorectal cancer as his previous doctor had identified a wall thickening in the descending colon on computed tomography as well as anemia.</p><p>Colonoscopy showed a 5-cm long submucosal tumor-like elevated lesion. A biopsy revealed amyloid deposits, and due to a lack of obvious damage in the other organs, a diagnosis of localized AL (amyloid light-chain) amyloidosis was made. Subsequently, a bone marrow biopsy revealed multiple myeloma, and the patient was transferred to the Department of Hematology for systemic chemotherapy.</p><p>In AL amyloidosis, amyloid is deposited mainly in the submucosal layer and presents characteristic endoscopic findings. In the present case, colorectal amyloidosis triggered the diagnosis of multiple myeloma.</p>

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