Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study

DOI Web Site 参考文献39件
  • Nakamura Kensuke
    Department of Critical Care Medicine, Yokohama City University Hospital Department of Emergency and Critical Care Medicine, Hitachi General Hospital
  • Hatakeyama Junji
    Department of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University
  • Liu Keibun
    Critical Care Research Group, The Prince Charles Hospital Institute for Molecular Bioscience (IMB), The University of Queensland Non-Profit Organization, ICU Collaboration Network (ICON)
  • Yamakawa Kazuma
    Department of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University
  • Nishida Takeshi
    Division of Trauma and Surgical Critical Care, Osaka General Medical Center
  • Ohshimo Shinichiro
    Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Inoue Shigeaki
    Department of Emergency and Critical Care Medicine, Wakayama Medical University
  • Hashimoto Satoru
    Non-Profit Organization, ICU Collaboration Network (ICON)
  • Maruyama Shuhei
    Department of Emergency and Critical Care Medicine, Kansai Medical University Medical Center
  • Kawakami Daisuke
    Department of Anesthesia and Critical Care, Kobe City Medical Center General Hospital
  • Ogata Yoshitaka
    Department of Critical Care Medicine, Yao Tokushukai General Hospital
  • Hayakawa Katsura
    Department of Emergency and Critical Care Medicine, Saitama Red Cross Hospital
  • Shimizu Hiroaki
    Acute Care Division, Hyogo Prefectural Harima Himeji General Medical Center
  • Oshima Taku
    Institute for Advanced Academic Research, Chiba University Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine
  • Fuchigami Tatsuya
    Department of Anesthesiology and Intensive Care Medicine, University of the Ryukyus Hospital
  • Nishida Osamu
    Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine

抄録

<p>The impact of nutrition therapy in the acute phase on post-intensive care syndrome (PICS) remains unclear. We conducted a multicenter prospective study on adult patients with COVID-19 who required mechanical ventilation for more than three days. The questionnaire was mailed after discharge. Physical PICS, defined as less than 90 points on the Barthel index (BI), was assigned as the primary outcome. We examined the types of nutrition therapy in the first week that affected PICS components. 269 eligible patients were evaluated 10 months after discharge. Supplemental parenteral nutrition (SPN) >400 ‍kcal/day correlated with a lower occurrence of physical PICS (10% vs 21.92%, p = 0.042), whereas the amounts of energy and protein provided, early enteral nutrition, and a gradual increase in nutrition delivery did not, and none correlated with cognitive or mental PICS. A multivariable regression analysis revealed that SPN had an independent impact on physical PICS (odds ratio 0.33, 95% CI 0.12–0.92, p = 0.034), even after adjustments for age, sex, body mass index and severity. Protein provision ≥1.2 ‍g/kg/day was associated with a lower occurrence of physical PICS (odds ratio 0.42, 95% CI 0.16–1.08, p = 0.071). In conclusion, SPN in the acute phase had a positive impact on physical PICS for ventilated patients with COVID-19.</p>

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