Comparing Characteristics of Pelvic High-grade Serous Carcinomas with and without Breast Cancer Gene Variants on MR Imaging
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- Saida Tsukasa
- Department of Radiology, Faculty of Medicine, University of Tsukuba
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- Shikama Ayumi
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba
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- Mori Kensaku
- Department of Radiology, Faculty of Medicine, University of Tsukuba
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- Ishiguro Toshitaka
- Department of Radiology, Faculty of Medicine, University of Tsukuba
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- Minaguchi Takeo
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba
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- Satoh Toyomi
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba
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- Nakajima Takahito
- Department of Radiology, Faculty of Medicine, University of Tsukuba
抄録
<p>Purpose: To compare MRI findings of high-grade serous carcinoma (HGSC) with and without breast cancer (BRCA) gene variants to explore the feasibility of MRI as a genetic predictor.</p><p>Methods: We retrospectively reviewed MRI data from 16 patients with BRCA variant-positive (11 patients of BRCA1 and 5 patients of BRCA2 variant-positive) and 32 patients with BRCA variant-negative HGSCs and evaluated tumor size, appearance, nature of solid components, apparent diffusion coefficient (ADC) value, time-intensity curve, several dynamic contrast-enhanced curve descriptors, and nature of peritoneal metastasis. Age, primary site, tumor stage, bilaterality, presence of lymph node metastasis, presence of peritoneal metastasis, and tumor markers were also compared between the groups with the Mann-Whitney U and chi-square tests.</p><p>Results: The mean tumor size of BRCA variant-positive HGSCs was 9.6 cm, and that of variant-negative HGSCs was 6.8 cm, with no significant difference (P = 0.241). No significant difference was found between BRCA variant-positive and negative HGSCs in other evaluated factors, except for age (mean age, 53 years old; range, 32–78 years old for BRCA variant-positive and mean age, 61 years old; range, 44–80 years old for BRCA variant-negative, P = 0.033). Comparing BRCA1 variant-positive and BRCA2 variant-positive HGSCs, BRCA1 variant-positive HGSCs were larger (P = 0.040), had greater Max enhancement (P = 0.013), Area under the curve (P = 0.013), and CA125 (P = 0.038), and had a higher frequency of lymph node metastasis (P = 0.049), with significance.</p><p>Conclusion: There was no significant difference in the MRI findings between patients with HGSCs with and without BRCA variants. Although studied in small numbers, BRCA1 variant-positive HGSCs were larger and more enhanced than BRCA2 variant-positive HGSCs with higher CA125 and more frequent lymph node metastases, and may represent more aggressive features.</p>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 23 (1), 18-26, 2024
日本磁気共鳴医学会