Adverse Events of COVID-19 Vaccine in Japanese University Students

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  • OTAKA Yuya
    Departmaent of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University
  • TAJIMA Kazuki
    Departmaent of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University
  • KIMURA Yuya
    Departmaent of Small Animal Internal Medicine I, School of Veterinary Medicine, Kitasato University
  • ITOH Naoyuki
    Departmaent of Small Animal Internal Medicine I, School of Veterinary Medicine, Kitasato University
  • KANAI Kazutaka
    Departmaent of Small Animal Internal Medicine II, School of Veterinary Medicine, Kitasato University
  • UENO Shunji
    Department Veterinary Public Health, School of Veterinary Medicine, Kitasato University

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Other Title
  • 日本の大学生におけるCOVID-19ワクチン接種後の副反応
  • ニホン ノ ダイガクセイ ニ オケル COVID-19 ワクチン セッシュ ゴ ノ フクハンノウ

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<p>Vaccination of the entire population aged five years and older is recommended to prevent severe cases of coronavirus disease 2019 (COVID-19) and the spread of infection. However, the high frequency of adverse events from the vaccination of young people has led to a hesitation in vaccination. This study aimed to collect information on adverse reactions to vaccination among young people and to provide these results for vaccination decisions.</p><p>A questionnaire was distributed to 1,099 students of Kitasato University School of Veterinary Medicine who were vaccinated with the mRNA-1273 (Moderna) COVID-19 vaccine. The data were collected from 231 (21%) respondents. Among the respondents, 220 (95.1%) were able to obtain information on adverse reactions before vaccination. The proportion of people who obtained information from social network services was significantly higher for women than for men (P<0.05). The incidence of adverse events after vaccination was higher at the second vaccination than at the first for all symptoms, with 97.4% showing some symptoms after the second vaccination. The mean duration or severity of each symptom was longer or higher at the second vaccination than at the first for all symptoms. Multiple regression analysis was performed for the duration and severity of each symptom at the time of the second vaccination. The results showed an association between each symptom and factors such as sex, symptoms at the time of the first vaccination, whether or not respondents kept pets, and whether or not they were informed of adverse reactions to the vaccine. After the second vaccination, 71.9% of students reported being able to attend school on the third day, and 89.6% of students reported being able to attend school on the fourth day.</p><p>This study clarifies the incidence of adverse events, duration and severity of symptoms, and number of days before being able to attend school after vaccination with mRNA-1273 in Japanese university students.</p>

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