滲出型加齢黄斑変性に対するアルクチゲニンの経口投与による予防効果

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  • Preventive effects of orally administered arctigenin on neovascular age-related macular degeneration

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<p>Neovascular age-related macular degeneration (nAMD) is an ocular disease characterized by choroidal neovascularization (CNV). For nAMD treatment, the intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs is commonly used. However, it can be highly invasive and burdensome for nAMD patients. Arctigenin is a component of the herbal medicine burdock root and known to exhibit anti-tumor and vascular normalizing effects. Here, we investigated the effect of oral administration of arctigenin on CNV formation. The murine CNV model was created by laser photocoagulation and arctigenin at 100 mg/kg was orally administrated once a day. CNV area, vascular leakage and the endothelial cell proliferation were evaluated. Oral administration of arctigenin suppressed CNV formation and vascular leakage. In the CNV lesion, the number of proliferating endothelial cells was reduced in the arctigenin-treated group. Furthermore, the effects of arctigenin were confirmed using in vitro experimental systems using human retinal microvascular endothelial cells (HRMECs). Arctigenin at 30 µM attenuated VEGF-induced HRMECs proliferation and migration. These findings suggest that oral administration of arctigenin has beneficial effects on choroidal neovascularization of nAMD.</p>

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