Short-and mid-term edoxaban treatment results for elderly emergency patients with non-valvular atrial fibrillation：A Japanese single-center study

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Background：Non-valvular atrial fibrillation (NVAF) in elderly patients is a serious risk factor for cardiogenic cerebral embolism. Aim：Here, we investigated the effect of edoxaban on the occurrence of stroke in NVAF cases. Methods：We investigated the clinical results, based on patient background and incidence of cerebral infarction, of 23 elderly patients aged 65 years or older with NVAF who were treated with edoxaban between April 2013 and March 2017. Results：Mean patient age (18 men, five women) was 77 ± 8 years. Of the cohort, 13 patients (56 %) had chronic NVAF and 10 patients (44 %) had paroxysmal NVAF. The loading amount of edoxaban was 30 mg in 16 cases (70 %) and 60 mg in seven cases (30 %). The mean estimated glomerular filtration rate was 61.6 ± 22.7 mL/min. The mean CHADS2 score was 2 ± 1.1 points. After edoxaban administration, one patient with gastric cancer recurrence required hospitalization for gastrointestinal bleeding. No new cases of cardiac cerebral infarction occurred during the observation period. Conclusions：Our study demonstrates that edoxaban is safe and that it effectively prevents cardiogenic cerebral embolism in elderly NVAF patients.

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