Gut microbiota and fecal metabolites in sustained unresponsiveness by oral immunotherapy in school-age children with cow's milk allergy
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- Shibata Ryohei
- Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Itoh Naoka
- Department of Pediatrics, National Hospital Organization Kanagawa National Hospital
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- Nakanishi Yumiko
- Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University
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- Kato Tamotsu
- Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University
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- Suda Wataru
- Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences
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- Nagao Mizuho
- Allergy Center, National Hospital Organization Mie National Hospital
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- Iwata Tsutomu
- The Graduate School of Tokyo Kasei University
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- Yoshida Hideo
- Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
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- Hattori Masahira
- Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences Graduate School of Advanced Science and Engineering, Waseda University
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- Fujisawa Takao
- Allergy Center, National Hospital Organization Mie National Hospital
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- Shimojo Naoki
- Center for Preventive Medical Sciences, Chiba University
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- Ohno Hiroshi
- Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences
説明
<p>Background: Oral immunotherapy (OIT) can ameliorate cow's milk allergy (CMA); however, the achievement of sustained unresponsiveness (SU) is challenging. Regarding the pathogenesis of CMA, recent studies have shown the importance of gut microbiota (Mb) and fecal water-soluble metabolites (WSMs), which prompted us to determine the change in clinical and gut environmental factors important for acquiring SU after OIT for CMA.</p><p>Methods: We conducted an ancillary cohort study of a multicenter randomized, parallel-group, delayed-start design study on 32 school-age children with IgE-mediated CMA who underwent OIT for 13 months. We defined SU as the ability to consume cow's milk exceeding the target dose in a double-blind placebo-controlled food challenge after OIT followed by a 2-week-avoidance. We longitudinally collected 175 fecal specimens and clustered the microbiome and metabolome data into 29 Mb- and 12 WSM-modules.</p><p>Results: During OIT, immunological factors improved in all participants. However, of the 32 participants, 4 withdrew because of adverse events, and only 7 were judged SU. Gut environmental factors shifted during OIT, but only in the beginning, and returned to the baseline at the end. Of these factors, milk- and casein-specific IgE and the Bifidobacterium-dominant module were associated with SU (milk- and casein-specific IgE; OR for 10 kUA/L increments, 0.67 and 0.66; 95%CI, 0.41-0.93 and 0.42-0.90; Bifidobacterium-dominant module; OR for 0.01 increments, 1.40; 95%CI, 1.10-2.03), and these associations were observed until the end of OIT.</p><p>Conclusions: In this study, we identified the clinical and gut environmental factors associated with SU acquisition in CM-OIT.</p>
収録刊行物
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- Allergology International
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Allergology International 73 (1), 126-136, 2024
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390017455877749120
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可