A 70-year-old Woman with Asymptomatic Ferroportin Disease

  • Ishikawa Tetsuya
    Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Japan
  • Tatsumi Yasuaki
    Department of Medical Biochemistry, Faculty of Pharmaceutical Sciences, Toho University, Japan
  • Kato Koichi
    Department of Medicine, Aichi Gakuin University School of Pharmacy, Japan
  • Hayashi Yumi
    Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Japan
  • Imai Norihiro
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan
  • Ito Takanori
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan
  • Ishizu Youji
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan
  • Ishigami Masatoshi
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Japan
  • Nihei Wataru
    Department of Medicine, Aichi Gakuin University School of Pharmacy, Japan
  • Kato Ayako
    Department of Medicine, Aichi Gakuin University School of Pharmacy, Japan
  • Hayashi Hisao
    Department of Medicine, Aichi Gakuin University School of Pharmacy, Japan

抄録

<p>A 59-year-old Japanese woman presented with hyperferritinemia. We decided against iron removal treatment because there were no symptoms or signs of iron-induced organ damage. A follow-up study revealed a gradual increase in transferrin saturation. The patient underwent a second examination at 66 years old. A liver biopsy showed substantial iron deposits in hepatocytes and Kupffer cells but no inflammation or fibrosis. Serum hepcidin-25 levels were highly parallel with hyperferritinemia. A genetic analysis revealed a G80S mutation in SLC40A1. These features are compatible with those of ferroportin disease. The patient remained asymptomatic at 70 years old, suggesting that the iron-loading condition may have been benign. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine advpub (0), 2024

    一般社団法人 日本内科学会

参考文献 (17)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ