Axillary Lymphadenopathy after COVID-19 Vaccination: Follow-up for Enlarged Lymph Nodes on MR Imaging

  • Kanemaru Noriko
    Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  • Yoshikawa Takeharu
    Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan
  • Miki Soichiro
    Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan
  • Nakao Takahiro
    Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan
  • Nakamura Yuta
    Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan
  • Fujimoto Kotaro
    Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan
  • Abe Osamu
    Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

抄録

<p>Purpose: The purpose of this study was to investigate the longitudinal MRI characteristic of COVID-19-vaccination-related axillary lymphadenopathy by evaluating the size, T2-weighted signal intensity, and apparent diffusion coefficient (ADC) values.</p><p>Methods: COVID-19-vaccination-related axillary lymphadenopathy was observed in 90 of 433 health screening program participants on the chest region of whole-body axial MRIs in 2021, as reported in our previous study. Follow-up MRI was performed at an interval of approximately 1 year after the second vaccination dose from 2022 to 2023. The diameter, signal intensity on T2-weighted images, and ADC of the largest enlarged lymph nodes were measured on chest MRI. The values were compared between the post-vaccination MRI and the follow-up MRI, and statistically analyzed.</p><p>Results: Out of the 90 participants who had enlarged lymph nodes of 5 mm or larger in short axis after the second vaccination dose, 76 participants (45 men and 31 women, mean age: 61 years) were enrolled in the present study. The median short- and long-axis diameter of the enlarged lymph nodes was 7 mm and 9 mm for post-vaccination MRI and 4 mm and 6 mm for follow-up MRI, respectively. The median signal intensity relative to the muscle on T2-weighted images decreased (5.1 for the initial post-vaccination MRI and 3.6 for the follow-up MRI, P < .0001). The ADC values did not show a notable change and remained in a normal range.</p><p>Conclusion: The enlarged axillary lymph nodes decreased both in size and in signal intensity on T2-weighted images of follow-up MRI. The ADC remained unchanged. Our findings may provide important information to establish evidence-based guidelines for conducting proper assessment and management of post-vaccination lymphadenopathy.</p>

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