The interface of geroscience and functional food, inflammation and trophic control

<p>In Japan, the number of the centenarians, continuously renewed for more than half a century since the late 20th century, exceed 90,000 by September 2022. We grow frequently aware of the era of the 100-year lifespan with life extension. Accordingly, to improve the quality of life (QOL) of the elderly and extend their healthy lifespan, the various biological functional changes declining with aging has been discussed in a multidisciplinary and comprehensive manner. Conversely, the factors of aging have been well studied, and the secret of healthy longevity is considered to be consist of a regular diet, with balanced "nutrition" and abstemious eating, moderate and habitual "exercise", and improvement of sleep quality and "communication" in a stress-free environment. Alternatively, chronic inflammation quietly accumulated with aging or the decline of physiological functions, including immunosenescence, is also important aging factors. In this issue, the transition of life span and aging research studied on various organisms is introduced, and geroscience research will be briefly reviewed, in which evidence from the unveiled life span genes and aging mechanisms will be brought geriatrics closer to human medicine. I will also introduce the possibility and impact of alleviation of chronic inflammation by functional foods and nutritional interventions on individual aging process, which are closely linked to the healthy life span extension. As an example, the results of long-term feeding of prebiotic lactobacillus to model mice to introduce the possibility of suppressing chronic inflammation by nutritional interventions with functional foods on aging linked to extending healthy lifespan.</p>