Feasibility of Diffusion-weighted Imaging (DWI) for Assessing Cerebrospinal Fluid Dynamics: DWI-fluidography in the Brains of Healthy Subjects

  • Fujiwara Shunrou
    Division of Molecular and Cellular Pharmacology, Department of Pathophysiology and Pharmacology, School of Pharmaceutical Science, Iwate Medical University, Yahaba, Iwate, Japan Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Ogasawara Kuniaki
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Chida Kohei
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Ogasawara Yasushi
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Nomura Jun-ichi
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Oshida Sotaro
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Fujimoto Kentaro
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Tsutsui Shota
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Setta Kengo
    Department of Neurosurgery, Iwate Medical University Hospital, Yahaba, Iwate, Japan
  • Yoshioka Yoshichika
    Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Iwate, Japan

抄録

<p>Purpose: The present study aimed to investigate whether diffusion-weighted imaging (DWI) can qualify and quantify cerebrospinal fluid (CSF) dynamics in the brains of healthy subjects. For this purpose, we developed new DWI-based fluidography and compared the CSF dynamics seen on the fluidography with two apparent diffusion coefficients obtained with different DWI signal models at anatomical spaces filled by CSF.</p><p>Methods: DWI with multiple b values was performed for 10 subjects using a 7T MRI scanner. DWI-fluidography based on the DWI signal variations in different motion probing gradient directions was developed for visualizing the CSF dynamics voxel-by-voxel. DWI signals were measured using an ROI in the representative CSF-filled anatomical spaces in the brain. For the multiple DWI signals, the mono-exponential and kurtosis models were fitted and two kinds of apparent diffusion coefficients (ADCC and ADCK) were estimated in each space using the Gaussian and non-Gaussian diffusion models, respectively.</p><p>Results: DWI-fluidography could qualitatively represent the features of CSF dynamics in each anatomical space. ADCs indicated that the motions at the foramen of Monro, the cistern of the velum interpositum, the quadrigeminal cistern, the Sylvian cisterns, and the fourth ventricle were more drastic than those at the subarachnoid space and anterior horns of the lateral ventricle. Those results seen in ADCs were identical to the findings on DWI-fluidography.</p><p>Conclusion: DWI-fluidography based on the features of DWI signals could show differences of CSF dynamics among anatomical spaces.</p>

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