Anti-neurofascin 155 Antibody-positive Neuropathy in a Human Immunodeficiency Virus-infected Patient
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- Okubo So
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Mano Tatsuo
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Sudo Atsushi
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Goto Ryoji
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Yano Satoka
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Hara Manato
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Ishiura Hiroyuki
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Satake Wataru
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
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- Yanagimoto Shintaro
- Department of Infectious Disease, Graduate School of Medicine, The University of Tokyo, Japan
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- Ogata Hidenori
- Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan
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- Toda Tatsushi
- Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan
Description
<p>Human immunodeficiency virus (HIV)-associated neuropathy is a common complication of HIV infection and has several clinical subtypes. HIV-associated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating neuropathy whose clinical features are known to differ from those of CIDP in the HIV-uninfected population. We herein report a case of CIDP in an HIV-infected patient who was finally diagnosed with anti-neurofascin 155 (NF155) antibody-positive neuropathy. The clinical features, including clinical findings and therapeutic responses, were typical of paranodal antibody-mediated neuropathy. To our knowledge, this is the first case of anti-NF155 antibody-associated neuropathy in an HIV-infected patient. </p>
Journal
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- Internal Medicine
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Internal Medicine 63 (4), 565-569, 2024-02-15
The Japanese Society of Internal Medicine