Outcomes of Endovascular Treatment for Infective Aortic Aneurysms　― A Multicenter Retrospective Study ―

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  • Lee Chih-Chun
    Department of Medical Education, Chang Gung Memorial Hospital
  • Chen Dong-Yi
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Chan Yi-Hsin
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Wu Victor Chien-Chia
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Cheng Yu-Ting
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University
  • Hung Kuo-Chun
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Lin Chia-Pin
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Tung Ying-Chang
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Hsiao Fu-Chih
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Yeh Jih-Kai
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Chu Pao-Hsien
    Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University
  • Chen Shao-Wei
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital

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<p>Background: In Taiwan, infective native aortic aneurysms (INAAs) are relatively common, so the aim of present study was to demonstrate the comparative outcomes of endovascular repair for thoracic and abdominal INAAs.</p><p>Methods and Results: Patients with naïve thoracic or abdominal INAAs managed with endovascular repair between 2001 and 2018 were included in this multicenter retrospective cohort. The confounding factors were adjusted with propensity score (PS). Of the 39 thoracic and 43 abdominal INAA cases, 41 (50%) presented with aneurysmal rupture, most of which were at the infrarenal abdominal (n=35, 42.7%) or descending thoracic aorta (n=25, 30.5%). Salmonella spp. was the most frequently isolated pathogen. The overall in-hospital mortality rate was 18.3%. The risks of in-hospital death and death due to rupture were significantly lower with thoracic INAAs (12.8% vs. 23.3%; PS-adjusted odds ratio (OR) 0.24, 95% confidence interval (CI) 0.06–0.96; 0.1% vs. 9.3%; PS-adjusted OR 0.11, 95% CI 0.01–0.90). During a mean follow-up of 2.5 years, the risk of all-cause death was significantly higher with thoracic INAAs (35.3% vs. 15.2%; PS-adjusted HR 6.90, 95% CI 1.69–28.19). Chronic kidney disease (CKD) was associated with death.</p><p>Conclusions: Compared with thoracic INAAs, endovascular repair of abdominal INAAs was associated with a significantly higher in-hospital mortality rate. However, long-term outcomes were worse for thoracic INAAs, with CKD and infections being the most important predictor and cause of death, respectively.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 88 (3), 309-318, 2024-02-22

    一般社団法人 日本循環器学会

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