Endothelial Glycocalyx Protection in Sepsis

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  • Levy JERROLD H
    Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine
  • Iba TOSHIAKI
    Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine

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<p> The glycocalyx serves as the covering layer of the luminal surface of vascular endothelial cells, comprising proteoglycans, glycosaminoglycans, and adherent plasma proteins. This intricate structure is crucial in promoting antithrombogenicity, controlling vascular permeability, regulating vascular tone, and managing leukocyte/platelet adhesion. However, during sepsis, the glycocalyx undergoes significant degradation through inflammatory mechanisms; this process can be further facilitated by treatment for sepsis and septic shock. Therefore, it is crucial to exercise careful management to avoid damage to the glycocalyx during sepsis treatment.</p>

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