A Case of Synchronous Bilateral Stage IV Breast Cancer with Different Subtypes

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  • 黄疸で発症し6年5カ月生存したサブタイプの異なる両側乳癌の1例

Abstract

<p>We present a case of synchronous bilateral Stage IV breast cancer. The patient is a 76-year-old woman who presented to the emergency room with a left breast mass, jaundice, and difficulty walking. She was diagnosed with hormone-positive locally advanced left breast cancer(cT4bN0) with multiple lung and pancreas metastasis. She had obstructive jaundice ; therefore, she underwent urgent endoscopic biliary drainage. Although endocrine therapy was initiated, the right breast mass enlarged and was diagnosed as HER2-positve breast cancer(cT2N0) after 1 year and 5 months. Despite anti-HER2 therapies, the right breast mass increased and right breast mastectomy was performed. She died of cancer pleurisy 6 years and 5 months after commencement of medication. Although pancreatic metastasis of breast cancer and molecular subtype discordance of synchronous bilateral Stage IV breast cancer are rare, biliary drainage, local control with mastectomy for early-stage breast cancer, and systemic pharmacotherapy may contribute to long-term survival.</p>

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