Most Azole-Susceptible Isolates of <i>Aspergillus fumigatus</i> in Hokkaido, Japan are Clustered with Worldwide Strains That Do Not Have Tandem Repeats in <i>Cyp51A</i> Promoter

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  • Fujiwara Takuya
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • Itoh Megumi
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
  • Matsumoto Naoya
    School of Veterinary Medicine, Azabu University Noboribetsu Marine Park Nixe
  • Koshizaki Yusuke
    JA-Hokkaidoukouseiren Obihiro Hospital
  • Saitou Syunpei
    JA-Hokkaidoukouseiren Obihiro Hospital
  • Yamada Kazutaka
    School of Veterinary Medicine, Azabu University
  • Toyotome Takahito
    Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine Medical Mycology Research Center, Chiba University

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  • Most Azole-Susceptible Isolates of Aspergillus fumigatus in Hokkaido, Japan are Clustered with Worldwide Strains That Do Not Have Tandem Repeats in Cyp51A Promoter

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Abstract

In this study, we analyzed Aspergillus fumigatus short tandem repeat patterns of 106 strains isolated from the outdoor air, clinical specimens, and king penguins (Aptenodytes patagonicus) with aspergillosis in Japan, and compared them with those of 668 strains from AfumID (including six isolates from Japan). The results showed that the isolates were classified into three major groups. Group II contained most of the azole-resistant strains with 34- and 46-bp tandem repeats in cyp51A promoter. As in our previous study, OKH50 and Env1 strains were classified in Group II. Most of the azole-susceptible strains obtained in Japan were classified in Group III.

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