Anti-contactin 1 Antibody-associated Membranous Nephropathy in Chronic Inflammatory Demyelinating Polyneuropathy with Several Autoantibodies
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- Shida Ryutaro
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Iwakura Takamasa
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Ohashi Naro
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Ema Chiemi
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Aoki Taro
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Tashiro Takeshi
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Ishigaki Sayaka
- Blood Purification Unit, Hamamatsu University School of Medicine, Japan
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- Isobe Shinsuke
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Fujikura Tomoyuki
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
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- Kato Akihiko
- Blood Purification Unit, Hamamatsu University School of Medicine, Japan
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- Nakamura Tomohiko
- Department of Neurology, Hamamatsu University School of Medicine, Japan
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- Fujigaki Yoshihide
- Department of Internal Medicine, Teikyo University School of Medicine, Japan
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- Shimizu Akira
- Department of Analytic Human Pathology, Nippon Medical School, Japan
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- Yasuda Hideo
- First Department of Medicine, Division of Nephrology, Hamamatsu University School of Medicine, Japan
抄録
<p>A 50-year-old man diagnosed with anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) was referred to our department for the evaluation of proteinuria. A kidney biopsy revealed membranous nephropathy (MN). Immunohistochemistry for CNTN1 revealed positive granular staining along the glomerular basement membrane, confirming anti-CNTN1 antibody-associated MN. Immunofluorescence showed a full-house pattern, and several autoantibodies, such as anti-nuclear antibody, anti-double-strand DNA antibody, and anti-cardiolipin antibody, were detected in the patient's serum. Although limited autoantibodies have been investigated in some of the reported cases, a variety of autoantibodies might be produced in anti-CNTN1 antibody-associated CIDP, accompanied by MN. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (5), 699-705, 2024-03-01
一般社団法人 日本内科学会