The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study
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- Shibata Mikiko
- Preventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine
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- Sato Kyoko Kogawa
- Preventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine
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- Koh Hideo
- Preventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine
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- Shibata Izumi
- Preventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine
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- Okamura Kaori
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine
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- Takeuchi Yuka
- Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine
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- Oue Keiko
- Health Administration Center (Kansai region), Nippon Telegraph and Telephone West Corporation
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- Morimoto Michio
- Health Administration Center (Kansai region), Nippon Telegraph and Telephone West Corporation
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- Hayashi Tomoshige
- Preventive Medicine and Environmental Health, Osaka Metropolitan University Graduate School of Medicine
抄録
<p>Background: Glomerular hyperfiltration has been reported to be associated with adverse renal outcomes in the general population. It is not known whether drinking pattern is associated with the risk of glomerular hyperfiltration in healthy individuals.</p><p>Methods: We prospectively followed middle-aged 8,640 Japanese men with normal renal function, no proteinuria, no diabetes, and no use of antihypertensive medications at entry. Data on alcohol consumption were gathered by questionnaire. Glomerular hyperfiltration was defined as estimated glomerular filtration rate (eGFR) ≥117 mL/min/1.73 m2, which was the upper 2.5th percentile value of eGFR in the entire cohort.</p><p>Results: During 46,186 person-years of follow-up, 330 men developed glomerular hyperfiltration. In a multivariate model, for men who consumed alcohol on 1–3 days per week, alcohol consumption of ≥69.1 g ethanol/drinking day was significantly associated with the risk of glomerular hyperfiltration (hazard ratio [HR] 2.37; 95% confidence interval [CI], 1.18–4.74) compared with non-drinkers. For those who consumed alcohol on 4–7 days per week, higher alcohol consumption per drinking day was associated with a higher risk of glomerular hyperfiltration: the HRs for alcohol consumption of 46.1–69.0, and ≥69.1 g ethanol/drinking day were 1.55 (95% CI, 1.01–2.38), and 1.78 (95% CI, 1.02–3.12), respectively.</p><p>Conclusion: For high drinking frequency per week, more alcohol intake per drinking day was associated with an increased risk of glomerular hyperfiltration, while for low drinking frequency per week, only very high alcohol intake per drinking day was associated with an increased risk of glomerular hyperfiltration in middle-aged Japanese men.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 34 (3), 137-143, 2024-03-05
日本疫学会