A case of micronodular thymic carcinoma with lymphoid hyperplasia treated with robot-assisted extended thymectomy

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  • ロボット支援下拡大胸腺摘出術を施行したMicronodular thymic carcinoma with lymphoid hyperplasiaの1例

Abstract

<p>Micronodular thymic carcinoma with lymphoid hyperplasia (MNCLH) is a rare disease similar to micronodular thymoma with lymphoid stroma (MNT). MNCLH can be clearly distinguished from MNT by the atypicality of tumor cells, and is tentatively considered a subtype of thymic squamous cell carcinoma in the WHO classification (5th edition). A 48-year-old man was referred to our department for further treatment of a well-defined nodule of 13 mm in diameter in the anterior mediastinum on chest CT. He had no myasthenic symptoms, and serum levels of CEA, SCC, and anti-acetylcholine receptor antibody titers were within normal limits. Thymoma was suspected; thus, a robot-assisted extended thymectomy was performed and the patient was discharged on the fourth day. Pathological examination revealed nodular lesions similar to MNT, but a diagnosis of MNCLH was made based on the findings of strong atypia, CD5, and c-KIT positivity. Since the disease was in the Masaoka I stage, no further treatment was given and the patient has been alive for one year without recurrence.</p>

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