Controlled Release of Lysozyme Using Polyvinyl Alcohol-Based Polymeric Nanofibers Generated by Electrospinning
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- Ogawa Riho
- Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University
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- Hara Kouji
- Laboratory of Nanofiber Technology, Gifu Pharmaceutical University Global Food/Healthcare Department, Mitsubishi Chemical Corporation
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- Kobayashi Ayaka
- West Japan Group, Commercial Department, Japan Division, Specialty Materials Business Group, Mitsubishi Chemical Corporation
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- Yoshimura Nobuyoshi
- Acetyl Polymers Laboratory, Polymers R&D Center, Polymers Division, Polymers & Compounds/MMA Business Group, Mitsubishi Chemical Corporation
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- Taniguchi Yutaka
- Acetyl Polymers Laboratory, Polymers R&D Center, Polymers Division, Polymers & Compounds/MMA Business Group, Mitsubishi Chemical Corporation
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- Yamazoe Eriko
- Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University
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- Ito Takaaki
- Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University
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- Tahara Kohei
- Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University Laboratory of Nanofiber Technology, Gifu Pharmaceutical University
抄録
<p>Polymeric nanofibers generated via electrospinning offer a promising platform for drug delivery systems. This study examines the application of electrospun polyvinyl alcohol (PVA) nanofibers for controlled lysozyme (LZM) delivery. By using various PVA grades, such as the degree of polymerization/hydrolysis, this study investigates their influence on nanofiber morphology and drug-release characteristics. LZM-loaded PVA monolithic nanofibers having 50% drug content exhibit efficient entrapment, wherein rapid dissolution is achieved within 30 min. The initial burst of LZM from the nanofiber was reduced as the LZM content was lowered. The initial dissolution is greatly influenced by the choice of PVA grade used; fully hydrolyzed PVA nanofibers demonstrate controlled release due to the reduced water solubility of PVA. Furthermore, coaxial electrospinning, which creates core–shell nanofibers with polycaprolactone as a controlled release layer, enables sustained LZM release over an extended period. This study confirms a correlation between PVA characteristics and controlled drug release and provides valuable insights into tailoring nanofiber properties for pharmaceutical applications.</p>
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 72 (3), 324-329, 2024-03-21
公益社団法人 日本薬学会