Microvascular Changes Are Associated with Proteinuria and EMG Changes in Patients with Type 2 Diabetes Using Video Capillaroscopy

DOI Web Site 参考文献15件
  • Rajaei Alireza
    Rheumatology Department, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Dehghan Pooneh
    Radiology Department, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Emtiazi Nikoo
    Department of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  • Afzalnia Azadeh
    Rajaei Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
  • Farsad Faraneh
    Rheumatology Department, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Hosseinian Seyed Mohamad
    Rheumatology Department, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran

抄録

<p>Objectives: Video capillaroscopy is a diagnostic method for evaluating microvascular changes in type 2 diabetes mellitus (T2DM). This study evaluated microvascular changes, including microvascular architecture, capillary distribution (morphology and density), and angiogenesis conditions in T2DM patients via video capillaroscopy.</p><p>Methods: A total of 256 patients with T2DM enrolled in this study. Based on electromyography (EMG)–nerve conduction velocity results, patients were divided into patients with normal and abnormal EMG. Microalbuminuria was assessed using biochemical urine analysis. Finally, video capillaroscopy was performed to evaluate changes in microvascular architecture, capillary distribution, and angiogenesis status.</p><p>Results: The differences between microalbuminuria in patients with normal and abnormal EMG were not significant. Other microvascular changes were not significant between normal and abnormal EMG groups. The patients with greater microalbuminuria were at risk of abnormal EMG 2.8 times higher than those with fewer microalbuminuria (odds ratio = 2.804; 1.034–7.601). However, EMG is not a risk factor for microvascular architecture alternation in T2DM (odds ratio = 1.069; 0.323–3.546).</p><p>Conclusions: Microvascular alternations are common in T2DM and early detection of these changes could help to avoid the progress of nephropathic complications. Also, video capillaroscopy provides a promising diagnostic method for the detection of microvascular alternations in T2DM.</p>

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