EEG and MRI studies in psychiatric disorders

Koshiyama Daisuke

doi:10.11249/jsbpjjpp.35.1_46

Mismatch negativity and gamma‐band oscillations are well known EEG indices that are expected to be useful in investigating the pathophysiology of schizophrenia. These EEG indices have been repeatedly reported to be impaired in patients with schizophrenia and have been shown to be associated with clinical symptoms. Since these EEG indices can also be measured in animals, they are being used in basic research using animal models. In addition, a series of large‐scale MRI studies have recently reported structural changes in gray matter and white matter in the cerebrum in patients with schizophrenia. In order to advance research to the next level, it is necessary to integrate the results of these large‐scale studies with the neurophysiological findings obtained to date to understand the pathophysiology of schizophrenia as a disorder of the global neural network. The clarification of dysfunction of the global neural network in patients with schizophrenia will make it possible to conduct animal experiments to study the pathophysiology for the disease, which is difficult to do in humans, and will serve as a basis for the development of new treatments.

EEG and MRI studies in psychiatric disorders

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