Analysis of subgingival microbiota and IL-1β, TNF-α and CX3CL1 levels in gingival crevicular fluid of fixed dental prostheses
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- ALARCÓN-SÁNCHEZ Mario Alberto
- Department of Microbiology, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero
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- CASTRO-ALARCÓN Natividad
- Department of Microbiology, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero
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- SANDOVAL-GUEVARA Daniel
- Department of Implantology and Oral Rehabilitation, Faculty of Dentistry, Autonomous University of Guerrero
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- VÁZQUEZ-VILLAMAR Mirna
- Agricultural Microbiology Laboratory, Faculty of Agricultural and Environmental Science, Autonomous University of Guerrero
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- FERNÁNDEZ-ACOSTA Karla
- Department of Implantology and Oral Rehabilitation, Faculty of Dentistry, Autonomous University of Guerrero
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- MÉNDEZ-GÓMEZ Mayra Yanet
- Department of Implantology and Oral Rehabilitation, Faculty of Dentistry, Autonomous University of Guerrero
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- PARRA-ROJAS Isela
- Obesity and Diabetes Research Laboratory, Faculty of Chemical-Biological Sciences, Autonomous University of Guerrero
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- ROMERO-CASTRO Norma Samanta
- Department of Implantology and Oral Rehabilitation, Faculty of Dentistry, Autonomous University of Guerrero
抄録
<p>Prosthetic biomaterials can affect the composition of the subgingival microbiota and consequently the production of proinflammatory cytokines, causing damage to the periodontium. A total of 40 patients were divided into two groups: 20 with monolithic zirconia (MZ) prostheses and 20 with porcelain fused to metal (PFM) with nickel-chromium (Ni-Cr) alloy prostheses. Subgingival plaque and gingival crevicular fluid samples were taken. The Checkerboard technique for DNA-DNA hybridization and the enzyme-linked immunosorbent assay technique were performed. Teeth with MZ presented a lower percentage of bleeding on probing and tooth mobility compared to teeth with PFM with Ni-Cr alloy. Prosthodontic teeth harbored higher total levels of the 18 bacterial species than non-prosthodontic teeth. There was a higher prevalence of S. gordonii and V. parvula species in PFM with Ni-Cr alloy compared to MZ. There was an increase in IL-1β, TNF-α and CX3CL1 levels in PFM with Ni-Cr alloy compared to MZ. MZ is a candidate biomaterial with fewer negative effects on the periodontium, allowing for longer prostheses longevity in the mouth.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 43 (2), 235-246, 2024-03-25
一般社団法人 日本歯科理工学会