Nationwide survey of analysis of poor prognostic factors for living donor liver transplantation for hepatocellular carcinoma.
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- MASAHIRO OHIRA
- Department of Gastroenterological and Transplant Surgery, Hiroshima University
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- AOKI GAKU
- Clinical Research Center in Hiroshima
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- YOSHIMURA KENICHI
- Medical Center for Translational and Clinical Research, Hiroshima University Hospital
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- SOEJIMA YUJI
- Department of Surgery, Shinshu University
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- EGUCHI SUSUMU
- Department of Surgery, Nagasaki University
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- UMESHITA KOJI
- Department of Gastroenterological Surgery, Osaka University
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- EGAWA HIROTO
- Department of Surgery, Institute of Gastroeterology, Tokyo Women's Medical University
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- OHDAN HIDEKI
- Department of Gastroenterological and Transplant Surgery, Hiroshima University
抄録
<p>Background: Current insurance coverage for liver transplantation (LT) for hepatocellular carcinoma (HCC) is based on the Milan criteria or the 5-5-500 criteria. We have analyzed risk factors based on updated nationwide data from Japan.</p><p>METHODS: Subjects were 516 LDLT cases for HCC performed between 2010 and 2018 at 37 centers nationwide. Cox proportional hazards model was used to analyze prognostic factors on recurrence-free survival rate in 474 cases within the new Japan criteria.</p><p>Results: The 5Y-OS and RFS rates for patients within and outside the new Japan criteria were 81% vs. 56% and 77% vs. 44%, respectively. The RFS for patients within the Milan criteria and outside the 5-5-500 criteria were worse compared with within the new Japan criteria. Multivariate analysis identified NLR 5 or higher and prior hepatectomy as independent risk factors.</p><p>Conclusions: The results of the nationwide survey showed that the new Japan criteria were valid, but as in previous studies, patients within the Milan criteria and outside the 5-5-500 criteria had a poor outcome. Poor prognostic factors for patients within the new Japan criteria were NLR 5 or higher and prior hepatectomy.</p>
収録刊行物
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- 移植
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移植 58 (Supplement), s167_1-s167_1, 2023
一般社団法人 日本移植学会
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詳細情報 詳細情報について
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- CRID
- 1390018198838334592
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- ISSN
- 21880034
- 05787947
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可