書誌事項
- タイトル別名
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- Altered metabolites of Kynurenine Pathway are relevant to the risk of neurodevelop- mental disorders.
- シンケイ ハッタツキ ニ オケル キヌレニン タイシャ サンブツ ゾウカ ガ タイジ エ オヨボス エイキョウ
この論文をさがす
説明
<p>The kynurenine pathway (KP) is a major route for the metabolism of the essential amino acid L-tryptophan (Trp) in mammalian cells. Activation of the KP during neuro-inflammation can lead to the production of various endogenous neuroactive metabolites that may impact brain functions and behaviors. Furthermore, neurotoxic metabolites and excitotoxicity resulting from KP activation can induce long-term changes in nutritional support, the glutamatergic system, and synaptic function. Therefore, investigating the role of KP metabolites during neurodevelopment is likely to enhance our understanding the pathophysiology of neurodevelopmental disorders, including autism spectrum dis- order (ASD). In this review, we elucidate alterations in KP metabolism during pregnancy and represent how KP metabolites during neurodevelopment period influence behavioral impairments in later stages of life.</p>
収録刊行物
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- 微量栄養素研究
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微量栄養素研究 40 (0), 87-91, 2023
日本微量栄養素学会
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詳細情報 詳細情報について
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- CRID
- 1390018198838817280
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- NII書誌ID
- AA11475606
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- ISSN
- 24366617
- 13462334
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- NDL書誌ID
- 033234333
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用可