COVID-19 fatality and DALYs, and associated metabolic disorders and ambient air pollutants in pre-Omicron era of the pandemic: an international comparative study
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- Ngatu Nlandu-Roger
- Department of Public Health, Kagawa University Faculty of Medicine
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- Tonduangu Daniel-Kuezina
- Department of Internal Medicine, Faculty of Medicine, University of Kinshasa
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- Munyeshyaka Emmanuel
- Department of Microbiology, Kagawa University Faculty of Medicine
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- Hirao Tomohiro
- Department of Public Health, Kagawa University Faculty of Medicine
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- Balenda Georges-Matondo
- Surgery Unit, Louis Pasteur Hospital
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- Yamadori Yusuke
- Department of Anesthesiology, Kagawa University Faculty of Medicine
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- Deguchi Takayuki
- Department of Public Health, Kagawa University Faculty of Medicine
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- Nsadi-Fwene Berthier
- Department of Surgery, Faculty of Medicine, University of Kinshasa
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- Lami Jose-Nzunzu
- Faculty of Pharmaceutical Sciences, University of Kinshasa
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- Akumwami Steeve
- Department of Anesthesiology, Kagawa University Faculty of Medicine
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- Kanda Kanae
- Department of Public Health, Kagawa University Faculty of Medicine
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- Murakami Akitsu
- Oncology and Palliative Care Center, Kagawa University Faculty of Medicine
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- Yandju Marie-Claire
- Department of Biology, Faculty of Sciences, University of Kinshasa
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- Nyembue Dieudonne-Tshipukane
- Department of Otorhinolaryngology, Faculty of Medicine, University of Kinshasa
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- Tshimpi Antoine
- Department of Internal Medicine, Faculty of Medicine, University of Kinshasa
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- Wembonyama Stanislas-Okitotsho
- School of Public Health, University of Goma
抄録
<p>Background: Air pollution and a number of metabolic disorders have been reported to increase the risk of severe COVID-19 outcomes. This study explored the association between severe COVID-19 outcomes, metabolic disorders and environmental air pollutants, at regional level, across 38 countries.</p><p>Methods: We conducted an ecological study using COVID-19 data related to countries of the Organization for Economic Cooperation and Development (OECD), with an estimated population of 1.4 billion. They were divided into 3 regions: 1. Europe & Middle east; 2. Americas (north, central & south America); 3. East-Asia & West Pacific. The outcome variables were: COVID-19 case-fatality rate (CFR) and disability-adjusted life years (DALYs) at regional level. Freely accessible datasets related to regional DALYs, demographics and other environmental pollutants were obtained from OECD, WHO and the World in Data websites. Generalized linear model (GLM) was performed to determine the regional determinants of COVID-19 CFR and DALYs using the aggregate epidemiologic data (Dec. 2019–Dec. 2021).</p><p>Results: Overall cumulative deaths were 65,000 per million, for mean CFR and DALYs of 1.31 (1.2)% and 17.35 (2.3) years, respectively. Globally, GLM analysis with adjustment for elderly population rate, showed that COVID-19 CFR was positively associated with atmospheric PM2.5 level (beta = 0.64(0.0), 95%CI: 0.06–1.35; p < 0.05), diabetes prevalence (beta = 0.26(0.1), 95%CI: 0.12–0.41; p < 0.001). For COVID-19 DALYs, positive associations were observed with atmospheric NOx level (beta = 0.06(0.0), 95%CI: 0.02–0.82; p < 0.05) and diabetes prevalence (beta = 0.32(0.2), 95%CI: 0.04–0.69; p < 0.05). At regional level, adjusted GLM analysis showed that COVID-19 CFR was associated with atmospheric PM2.5 level in the Americas and East-Asia & Western Pacific region; it was associated with diabetes prevalence for countries of Europe & Middle east and East-Asia & Western Pacific region. Furthermore, COVID-19 DALYs were positively associated with atmospheric PM2.5 and diabetes prevalence for countries of the Americas only.</p><p>Conclusion: These findings confirm that diabetes and air pollution increase the risk of disability and fatality due to COVID-19, with disparities in terms of their impact. They suggest that efficient preventive and management programs for diabetes and air pollution countermeasures would have curtailed severe COVID-19 outcome rates.</p>
収録刊行物
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- Environmental Health and Preventive Medicine
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Environmental Health and Preventive Medicine 29 (0), 24-24, 2024
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詳細情報 詳細情報について
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- CRID
- 1390018274813649280
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- ISSN
- 13474715
- 1342078X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用可