Asthma is a risk factor for general fatigue of long COVID in Japanese nation-wide cohort study

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  • Sunata Keeya
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Miyata Jun
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Terai Hideki
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine Keio Cancer Center, Keio University School of Medicine
  • Matsuyama Emiko
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Watase Mayuko
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine Department of Respiratory Medicine, National Hospital Organization Tokyo Medical Center
  • Namkoong Ho
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine Department of Infectious Diseases, Keio University School of Medicine
  • Asakura Takanori
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine Department of Respiratory Medicine, Kitasato University Kitasato Institute Hospital Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy
  • Masaki Katsunori
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Chubachi Shotaro
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Ohgino Keiko
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Kawada Ichiro
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine Research Centers and Institutes, Health Center, Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
  • Harada Norihiro
    Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine
  • Sasano Hitoshi
    Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine
  • Nakamura Ai
    Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine
  • Kusaka Yu
    Department of Respiratory Medicine, Ome Municipal General Hospital
  • Ohba Takehiko
    Department of Respiratory Medicine, Ome Municipal General Hospital
  • Nakano Yasushi
    Department of Internal Medicine, Kawasaki Municipal Ida Hospital
  • Nishio Kazumi
    Department of Internal Medicine, Kawasaki Municipal Ida Hospital
  • Nakajima Yukiko
    Department of Internal Medicine, Kawasaki Municipal Ida Hospital
  • Suzuki Shoji
    Department of Pulmonary Medicine, Saitama City Hospital
  • Yoshida Shuichi
    Department of Pulmonary Medicine, Saitama City Hospital
  • Tateno Hiroki
    Department of Pulmonary Medicine, Saitama City Hospital
  • Ishii Makoto
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
  • Fukunaga Koichi
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine

抄録

<p>Background: Multiple prolonged symptoms are observed in patients who recover from an acute COVID-19 infection, which is defined as long COVID. General fatigue is frequently observed in patients with long COVID during acute and post-acute phases. This study aimed to identify the specific risk factors for general fatigue in long COVID.</p><p>Methods: Hospitalized patients with COVID-19 aged over 18 years were enrolled in a multicenter cohort study at 26 medical institutions. Clinical data during hospitalization and patient-reported outcomes after discharge were collected from medical records, paper-based questionnaires, and smartphone apps.</p><p>Results: Among prolonged symptoms through 1-year follow-ups, general fatigue was the most interfering symptom in daily life. Patients with protracted fatigue at all follow-up periods had lower quality of life scores at the 12-month follow-up. Univariate logistic regression analysis of the presence or absence of general fatigue at the 3-month, 6-month, and 12-month follow-ups identified asthma, younger age, and female sex as risk factors for prolonged fatigue. Multivariable logistic regression analysis revealed that asthma was an independent risk factor for persistent fatigue during the 12-month follow-up period. Longitudinal changes in the symptoms of patients with or without asthma demonstrated that general fatigue, not cough and dyspnea, was significantly prolonged in patients with asthma.</p>

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