What Was Produced by Fermentation? From Elucidation of Ingredients to Verification of Effects on Skin
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- Kotaka Aki
- FANCL Research Institute, FANCL Corporation
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- Okuda Yo
- Research Center, Maruzen Pharmaceuticals Co., Ltd.
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- Ohto Nobuaki
- Research Center, Maruzen Pharmaceuticals Co., Ltd.
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- Mitsui Ryoji
- Department of Bioscience, Faculty of Lifescience, Okayama University of Science
Bibliographic Information
- Other Title
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- 発芽玄米発酵液に含まれる成分の解明から肌への効果検証まで
Abstract
<p>We have developed a fermentation liquid based on germinated brown rice, which has a high nutritional value, using the yeast Lachancea thermotolerans. The fermented liquid is known to be beneficial to the skin and to contain amino acids, but little is known about its other components. Metabolomics is the study of small molecules and has been used in the pharmaceutical and food industries to identify metabolic changes. We used a metabolomics approach to comprehensively analyze the fermentation liquid, determine the components of the fermentation, and correlate them with functionality for the skin. Acetylpolyamines were identified as a characteristic metabolite of the fermentation liquid. An in vitro evaluation of the efficacy of polyamines and their derivatives, acetylpolyamines, confirmed that they promoted hyaluronic acid production in the epidermis and dermis, inhibited melanin production, and promoted glutathione production. Next, the permeability of acetylpolyamines and polyamines was evaluated using a three-dimensional human epidermis experimental model. Polyamines and acetylpolyamines penetrated to the lower part of the cornified layer in 1 h, whereas the permeability of the granular layer differed among acetylpolyamines. Using a three-dimensional human epidermis model, hyaluronic acid production around the basement membrane induced by permeating spermidine trihydrochloride and N8-Acetylspermidine dihydrochloride was confirmed. Using a metabolomics approach, we have contributed to a better understanding of the active compounds present in fermented liquids that can be used for skin wellness.</p>
Journal
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- Journal of Society of Cosmetic Chemists of Japan
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Journal of Society of Cosmetic Chemists of Japan 58 (1), 45-54, 2024-03-20
The Society of Cosmetic Chemists of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390018428978613888
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- ISSN
- 18844146
- 03875253
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed