A Case of Eosinophilic Granulomatosis with Polyangiitis Presenting as Granulomatous Arteritis

DOI

Bibliographic Information

Other Title
  • 肉芽腫性動脈炎を呈した好酸球性多発血管炎性肉芽腫症の1例～診断の根拠となる特異的な病理組織所見の検討

Abstract

<p>A 65-year-old male was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) based upon findings of adult-onset asthma, polyneuropathy, renal dysfunction, intestinal involvement, and laboratory findings of elevated serum IgE levels and eosinophils counts in the peripheral blood, as well as positive anti-MPO neutrophil cytoplasmic antibody. He developed livedo, infiltrative erythema with a few subcutaneous nodules on the lower extremities. Histopathological examination revealed exclusive involvement of muscular vessel in the dermo-subcutaneous junction. Higher magnification revealed fibrinoid necrosis of the vessel wall with neutrophil infiltration and marked angiocentric infiltration of CD68-positive histiocytes, and a number of eosinophil infiltration. Elastica van Gieson staining revealed disrupted internal elastic lamina, and a diagnosis of granulomatous arteritis was made. Granulomatous arteritis is rare in EGPA. We emphasize that those histopathological findings observed in the present case are characteristic features of EGPA different from other granulomatous vasculitis. In addition, we reviewed previous cases of granulomatous arteritis in patients with EGPA, and discussed differential diagnosis of granulomatous arteritis of EGPA.</p>

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Details 詳細情報について

  • CRID
    1390018428979280128
  • DOI
    10.14924/dermatol.134.743
  • ISSN
    13468146
    0021499X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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