Does Neoadjuvant Chemoradiotherapy Have an Additional Effect to Lateral Pelvic Lymph Node Dissection for Rectal Cancer?

DOI Web Site 参考文献21件
  • Takabatake Kazuya
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Shimizu Hiroki
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Kuriu Yoshiaki
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Arita Tomohiro
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Kiuchi Jun
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Morimura Ryo
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Shiozaki Atsushi
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Ikoma Hisashi
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Kubota Takeshi
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Fujiwara Hitoshi
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine
  • Otsuji Eigo
    Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine

抄録

<p>Objectives: A total mesenteric excision (TME) with lateral pelvic lymph node dissection (LLND) is the standard treatment for advanced low rectal cancer in Japan. Recently, neoadjuvant (chemo) radiotherapy (n (C) RT) has been used with LLND to improve outcomes at multiple Japanese institutes. This study evaluates the benefits of adding nCRT to TME with LLND.</p><p>Methods: Seventy-two consecutive patients who underwent TME and LLND with or without nCRT between 2006-2019 to treat advanced low rectal cancer were retrospectively reviewed. The clinicopathological data were compared and the risk factors for local recurrence were evaluated.</p><p>Results: Fifty-seven patients (79.1%) underwent TME and LLND with nCRT, and 15 patients (20.9%) without nCRT. There was no significant difference in the clinicopathological characteristics except the clinical T stage. The occurrence of postoperative complications was statistically insignificant. The 5-year local recurrence rate of patients with nCRT was significantly lower than those without (4.0% versus 26.6%, in all patients, p=0.002). Multivariate analysis revealed that the absence of nCRT was an independent risk factor for local recurrences in patients who underwent TME with LLND (hazard ratio: 6.04, p=0.04).</p><p>Conclusions: The administration of nCRT prevented local recurrences more effectively in patients with advanced low rectal cancer who underwent TME with LLND.</p>

収録刊行物

参考文献 (21)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ