Testicular Leydig Cell Tumor in a Child With Secondary GnRH-Dependent Precocious Puberty Before Surgery: A Case Report With a Review of Clinical Characteristics From 24 Pediatric Cases in Japan

DOI
  • Kuda Masaaki
    Department of Digestive and General Surgery, University of the Ryukyus
  • Shibui Yuichi
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University
  • Takemoto Junkichi
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University
  • Souzaki Ryota
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University
  • Kohashi Kenichi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
  • Kinoshita Yoshiaki
    Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences
  • Taguchi Tomoaki
    Fukuoka College of Health Sciences
  • Tajiri Tatsuro
    Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University
  • Ieiri Satoshi
    Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University
  • Takatsuki Mitsuhisa
    Department of Digestive and General Surgery, University of the Ryukyus

Bibliographic Information

Other Title
  • 腫瘍摘出術前にGnRH依存性思春期早発症への移行が確定診断された小児精巣Leydig細胞腫の1例
  • ―本邦報告24例からみた臨床的特徴―

Description

<p>We report the case of a 10-year-old boy who presented with secondary GnRH-dependent precocious puberty caused by a testicular Leydig cell tumor. He was initially followed up by the pediatric endocrinology department with the diagnosis of mental retardation and growth hormone deficiency. At 9 years and 10 months of age, a rapid increase in height, skeletal growth acceleration, and penile growth was seen. He was hospitalized for examination at the previous hospital. He was diagnosed with GnRH-dependent precocious puberty and referred to our department with the suspicion of a testicular tumor. Testicular ultrasonography showed a hypoechoic left testicular mass with a diameter of 10 mm. Positron emission tomography-computed tomography revealed an accumulation of fluorodeoxyglucose in the left testicle, and the undeniable presence of malignancy. Therefore, a left orchiectomy was performed. The pathological diagnosis was a Leydig cell tumor; however, there were no histopathological features of malignancy. There are few pediatric case reports of Leydig cell tumors in Japan; this is the 24th reported case. Furthermore, this is the first case in which GnRH-dependent precocious puberty was diagnosed before surgery. We reviewed the clinical characteristics of previous Japanese pediatric case reports and concluded that pediatric Leydig cell tumor should be differentiated when prepubertal overgrowth symptoms are observed. Early diagnosis could be expected by performing testicular ultrasonography.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390018451149552000
  • DOI
    10.11164/jjsps.60.2_172
  • ISSN
    21874247
    0288609X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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