A Comparison of Alanine Aminotransferase Normalization between Pemafibrate and Bezafibrate in Patients with Nonalcoholic Fatty Liver Disease
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- Yamada-Shimizu Michiko
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Tamaki Nobuharu
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Kurosaki Masayuki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Uchihara Naoki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Suzuki Keito
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Tanaka Yuki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Miyamoto Haruka
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Ishido Shun
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Nobusawa Tsubasa
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Matsumoto Hiroaki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Keitoku Taisei
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Higuchi Mayu
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Takaura Kenta
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Tanaka Shohei
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Maeyashiki Chiaki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Yasui Yutaka
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Takahashi Yuka
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Tsuchiya Kaoru
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Nakanishi Hiroyuki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
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- Izumi Namiki
- Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Japan
抄録
<p>Objective Pemafibrate is a recently developed selective peroxisome proliferator-activated receptor alpha modulator that can improve alanine aminotransferase (ALT) levels in patients with nonalcoholic fatty liver disease (NAFLD). However, the effectiveness of ALT normalization with pemafibrate and bezafibrate, a traditional fibrate, has not been compared. </p><p>Methods In this retrospective study, we compared the effects of pemafibrate and bezafibrate on ALT normalization in patients with NAFLD. The primary endpoint was the ALT normalization rate at 12 months after administration. </p><p>Patients Twenty and 14 patients with NAFLD receiving pemafibrate and bezafibrate, respectively, were included in this retrospective analysis. All patients had elevated ALT levels and dyslipidemia at entry. </p><p>Results The ALT normalization rates at 3, 6, and 12 months were 40%, 55%, and 60% for pemafibrate and 14.3%, 28.6%, and 14.3% for bezafibrate, respectively. The ALT normalization rate at 12 months was significantly higher in patients treated with pemafibrate than in those treated with bezafibrate (p=0.01). Pemafibrate, when compared with bezafibrate, was shown to be a significant factor for ALT normalization in a multivariable analysis with an adjusted odds ratio (95% confidence interval) of 13.8 (1.6-115, p=0.01). </p><p>Conclusion Pemafibrate is effective in ALT normalization in patients with NAFLD and may be used as a treatment for NAFLD. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (9), 1185-1190, 2024-05-01
一般社団法人 日本内科学会